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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332384
Species: Mus musculus
RGD Object: Gene
Symbol: Ren1
Name: renin 1 structural
Acc ID: CHEBI:3011
Term: benazepril
Definition: A benzazepine that is benazeprilat in which the carboxy group of the 2-amino-4-phenylbutanoic acid moiety has been converted to the corresponding ethyl ester. It is used (generally as its hydrochloride salt) as a prodrug for the angiotensin-converting enzyme inhibitor benazeprilat in the treatment of hypertension and heart failure.
Chemical ID: MESH:C044946
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ren1increases activityISORen (Rattus norvegicus)6480464CTDbenazepril results in increased activity of REN proteinPMID:11501062
Ren1increases expressionISOREN (Homo sapiens)6480464CTDbenazepril results in increased expression of REN proteinPMID:1316404
Ren1multiple interactionsISORen (Rattus norvegicus)6480464CTD[benazepril co-treated with Valsartan] results in increased activity of REN proteinPMID:11501062
Ren1multiple interactionsISOREN (Homo sapiens)6480464CTD[benazepril co-treated with Valsartan] results in increased activity of REN proteinPMID:10836730
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