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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736627
Species: Homo sapiens
RGD Object: Gene
Symbol: FN1
Name: fibronectin 1
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FN1affects bindingEXP 6480464CTDFN1 protein binds to CopperPMID:23896426
FN1multiple interactionsEXP 6480464CTD[FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; [NSC 689534 binds to Copper] which results in increased expression of FN1 mRNA; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]PMID:18346929 PMID:20971185
FN1increases expressionISOFn1 (Rattus norvegicus)6480464CTDCopper deficiency results in increased expression of FN1 mRNAPMID:17418555
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