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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionEXP 6480464CTDCopper results in decreased expression of CDKN1A mRNAPMID:30556269
Cdkn1aincreases expressionEXP 6480464CTDCopper results in increased expression of CDKN1A mRNAPMID:22465980
Cdkn1amultiple interactionsEXP 6480464CTD[ATP7B protein affects the susceptibility to Copper] which affects the expression of CDKN1A mRNAPMID:23112546
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDCopper results in increased expression of CDKN1A proteinPMID:15880691
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Chelating Agents binds to Copper] which results in increased expression of CDKN1A mRNA; [Chelating Agents binds to Copper] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to 2-(2-aminoethyl)pyridine] which results in increased expression of CDKN1A protein; [Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein; [Copper results in increased activity of TP53 protein] which results in increased expression of CDKN1A mRNA; [NSC 689534 binds to Copper] which results in increased expression of CDKN1A mRNA; Tretinoin inhibits the reaction [[Copper binds to Isatin binds to trimethylenediamine] which results in increased expression of CDKN1A protein]PMID:16391388 PMID:17327230 PMID:20971185 PMID:30911355
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