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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69313
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ache
Name: acetylcholinesterase
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Achedecreases expressionEXP 6480464CTDCopper results in decreased expression of ACHE proteinPMID:23613148
Acheincreases activityEXP 6480464CTDCopper results in increased activity of ACHE proteinPMID:23354609
Achemultiple interactionsEXP 6480464CTD[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of ACHE protein; Copper inhibits the reaction [Aluminum results in decreased activity of ACHE protein]; Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in decreased activity of ACHE protein]PMID:23354609 PMID:32881150
Achemultiple interactionsISOAche (Mus musculus)6480464CTD[Copper co-treated with Cholesterol] results in increased activity of ACHE protein; Clioquinol inhibits the reaction [[Copper co-treated with Cholesterol] results in increased activity of ACHE protein]PMID:25856695
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