GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sod3 | increases expression | ISO | Sod3 (Mus musculus) | 6480464 | CTD | Copper results in increased expression of SOD3 mRNA | PMID:16629173 PMID:18977292 | Sod3 | multiple interactions | ISO | Sod3 (Mus musculus) | 6480464 | CTD | [Copper co-treated with ATOX1 protein] results in increased activity of SOD3 protein; [Copper promotes the reaction [ATOX1 protein binds to SOD3 promoter]] which results in increased expression of SOD3 mRNA; [Copper promotes the reaction [ATOX1 protein binds to SOD3 promoter]] which results in increased expression of SOD3 protein; Copper inhibits the reaction [Streptozocin results in decreased activity of SOD3 protein]; Copper promotes the reaction [ATOX1 protein binds to SOD3 promoter]; SOD3 protein inhibits the reaction [[Copper co-treated with Hydrogen Peroxide] results in increased degradation of Hyaluronic Acid] | PMID:18165226 PMID:18977292 PMID:23884884 | | ||||||||||||||||||||||
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