GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmox1 | decreases expression | EXP | | 6480464 | CTD | Copper deficiency results in decreased expression of HMOX1 protein | PMID:21784888 | Hmox1 | increases expression | EXP | | 6480464 | CTD | Copper deficiency results in increased expression of HMOX1 mRNA; Copper deficiency results in increased expression of HMOX1 protein | PMID:15173392 | Hmox1 | multiple interactions | EXP | | 6480464 | CTD | [ATP7B protein affects the susceptibility to Copper] which affects the expression of HMOX1 mRNA; [Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of HMOX1 mRNA; [Copper co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein; Copper promotes the reaction [[Iron co-treated with Diethylnitrosamine] results in increased expression of HMOX1 protein] | PMID:20302851 PMID:23112546 | Hmox1 | increases expression | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | Copper analog results in increased expression of HMOX1 protein; Copper results in increased expression of HMOX1 mRNA; Copper results in increased expression of HMOX1 protein | PMID:15297030 PMID:16093525 PMID:18078826 PMID:23882024 | Hmox1 | increases expression | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | Copper results in increased expression of HMOX1 mRNA; Copper results in increased expression of HMOX1 protein | PMID:17244614 PMID:19747488 PMID:19888908 PMID:24892424 | Hmox1 | multiple interactions | ISO | Hmox1 (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene co-treated with Copper] results in increased expression of HMOX1 mRNA; [beta-Naphthoflavone co-treated with Copper] results in increased expression of HMOX1 mRNA; [Methylcholanthrene co-treated with Copper] results in increased expression of HMOX1 mRNA; [Tetrachlorodibenzodioxin co-treated with Copper] results in increased expression of HMOX1 mRNA; Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]; pyrazolanthrone inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]; pyrrolidine dithiocarbamic acid promotes the reaction [Copper results in increased expression of HMOX1 mRNA]; SB 203580 inhibits the reaction [Copper results in increased expression of HMOX mRNA]; Tetradecanoylphorbol Acetate inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]; Triethylenephosphoramide inhibits the reaction [Copper deficiency inhibits the reaction [[Heme binds to HPX protein] which results in increased expression of HMOX1 protein]]; U 0126 inhibits the reaction [Copper results in increased expression of HMOX1 mRNA] | PMID:15297030 PMID:18078826 PMID:19039664 | Hmox1 | multiple interactions | ISO | HMOX1 (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in increased expression of HMOX1 mRNA; [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 mRNA; [Chitosan metabolite results in decreased susceptibility to Copper] which results in increased expression of HMOX1 protein; [Copper co-treated with [arsenic trichloride results in increased abundance of Arsenic]] results in increased expression of HMOX1 mRNA; [Disulfiram binds to Copper] which results in decreased expression of HMOX1 mRNA; [ethyl maltol results in increased susceptibility to [Copper Sulfate results in increased abundance of Copper]] which results in increased expression of HMOX1 mRNA; [ethyl maltol results in increased susceptibility to [Copper Sulfate results in increased abundance of Copper]] which results in increased expression of HMOX1 protein; [NSC 689534 binds to Copper] which results in increased expression of HMOX1 mRNA; [NSC 689534 binds to Copper] which results in increased expression of HMOX1 protein; [Organoselenium Compounds binds to Copper] which results in increased expression of HMOX1 mRNA; ATP7B gene mutant form inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]; Copper inhibits the reaction [tetrathiomolybdate analog results in increased expression of HMOX1 protein]; Copper promotes the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Copper results in increased expression of HMOX1 mRNA]; RELA mRNA affects the reaction [Copper results in increased expression of HMOX1 mRNA] | PMID:19323979 PMID:19747488 PMID:20888885 PMID:20971185 PMID:24690739 PMID:24892424 PMID:25167922 PMID:25542178 PMID:30911355 PMID:33271249 PMID:35809665 | | ||||||||||||||||||||||
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