GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | increases expression | EXP | | 6480464 | CTD | Copper results in increased expression of BAX protein | PMID:30556269 | Bax | multiple interactions | EXP | | 6480464 | CTD | [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX mRNA; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX protein; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased expression of BAX protein]; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA]; Rutin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein] | PMID:22085843 PMID:32881150 PMID:34577062 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Copper analog results in increased expression of BAX protein; Copper results in increased expression of BAX protein | PMID:22000994 PMID:34676557 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | Copper results in increased expression of BAX mRNA; Copper results in increased expression of BAX protein | PMID:15880691 PMID:16962711 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX mRNA; [Copper Sulfate results in increased abundance of Copper] which results in increased expression of BAX protein | PMID:31491480 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in decreased expression of BAX mRNA; [Copper co-treated with Disulfiram] results in increased expression of BAX protein; [Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein; Luteolin affects the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased expression of BAX protein] | PMID:23033007 PMID:29115570 PMID:30911355 | |
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