GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL6 | decreases secretion | EXP | | 6480464 | CTD | Copper results in decreased secretion of IL6 protein | PMID:2107032 | IL6 | multiple interactions | EXP | | 6480464 | CTD | [Chelating Agents binds to Copper] which results in decreased expression of IL6 mRNA; [diglycyl-histidine co-treated with Copper] inhibits the reaction [TNF protein results in increased secretion of IL6 protein]; [Disulfiram binds to Copper] which results in increased expression of IL6 mRNA; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 protein | PMID:23285694 PMID:24690739 PMID:27816692 PMID:30911355 | IL6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | Copper promotes the reaction [APP protein modified form results in increased expression of and results in increased secretion of IL6 protein] | PMID:27122238 | IL6 | multiple interactions | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | [Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; [Iron co-treated with Diethylnitrosamine co-treated with Copper] results in decreased expression of IL6 mRNA; Curcumin inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein]; Deferoxamine inhibits the reaction [[Copper Sulfate results in increased abundance of Copper] which results in increased expression of IL6 protein] | PMID:20302851 PMID:25813056 PMID:34577062 | | ||||||||||||||||||||||
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