GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | decreases expression | EXP | | 6480464 | CTD | Copper results in decreased expression of EGFR mRNA | PMID:17205981 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of EGFR protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Chelating Agents binds to Copper] which affects the expression of EGFR mRNA; [Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein; [Copper binds to neocuproine] which results in increased phosphorylation of EGFR protein; [Copper binds to Oxyquinoline] which results in increased phosphorylation of EGFR protein; [Copper binds to pyrrolidine dithiocarbamic acid] which results in increased phosphorylation of EGFR protein; [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; [NSC 689534 binds to Copper] which results in increased expression of EGFR mRNA; [Thiosemicarbazones binds to Copper] which results in increased phosphorylation of EGFR protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of EGFR protein]; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] | PMID:18346929 PMID:20931265 PMID:20971185 PMID:30911355 | | ||||||||||||||||||||||
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