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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2901
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:30050
Term: gold(0)
Definition: An elemental gold that has formula Au.
Chemical ID: MESH:D006046
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6increases secretionISOIl6 (Mus musculus)6480464CTDGold results in increased secretion of IL6 proteinPMID:22155353
Il6multiple interactionsISOIl6 (Mus musculus)6480464CTD[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL6 proteinPMID:19695318 PMID:22155353
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTD[Polyethylene Glycols binds to Gold] which results in increased expression of IL6 protein; [Polyethyleneimine binds to Gold] which results in increased expression of IL6 protein; [Thioctic Acid binds to Gold] which results in increased expression of IL6 proteinPMID:28433809
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