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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2526
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hbegf
Name: heparin-binding EGF-like growth factor
Acc ID: CHEBI:30045
Term: divanadium pentaoxide
Definition: A vanadium oxide that has formula O5V2.
Chemical ID: MESH:C066075
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hbegfincreases expressionISOHBEGF (Homo sapiens)6480464CTDvanadium pentoxide results in increased expression of HBEGF mRNA; vanadium pentoxide results in increased expression of HBEGF proteinPMID:11159045 PMID:12676768 PMID:17459161
Hbegfmultiple interactionsISOHBEGF (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA]; Acetylcysteine inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA]; RTKI cpd inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA]; SB 203580 inhibits the reaction [vanadium pentoxide results in increased expression of HBEGF mRNA]PMID:11159045 PMID:12676768
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