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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551496
Species: Mus musculus
RGD Object: Gene
Symbol: Abcg2
Name: ATP binding cassette subfamily G member 2 (Junior blood group)
Acc ID: CHEBI:3001
Term: beclomethasone
Definition: A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively.
Chemical ID: MESH:D001507
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg2increases activityISOABCG2 (Homo sapiens)6480464CTDBeclomethasone results in increased activity of ABCG2 proteinPMID:16442095
Abcg2multiple interactionsISOABCG2 (Homo sapiens)6480464CTDBeclomethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]PMID:15365089 PMID:16442095
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