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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737039
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN2A
Name: cyclin dependent kinase inhibitor 2A
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN2Adecreases expressionEXP 6480464CTDarsenite results in decreased expression of CDKN2A mRNA; arsenite results in decreased expression of CDKN2A proteinPMID:21040761
CDKN2Adecreases methylationEXP 6480464CTDarsenite results in decreased methylation of CDKN2A promoterPMID:23974009
CDKN2Aincreases methylationEXP 6480464CTDarsenite results in increased methylation of CDKN2A genePMID:21040761
CDKN2Amultiple interactionsEXP 6480464CTDarsenite promotes the reaction [G3BP1 protein binds to CDKN2A mRNA]; arsenite promotes the reaction [G3BP1 protein binds to CDKN2A protein]; Decitabine inhibits the reaction [arsenite results in decreased expression of CDKN2A protein]; U 0126 inhibits the reaction [arsenite results in decreased expression of CDKN2A protein]PMID:21040761 PMID:32406909
CDKN2Aincreases expressionISOCdkn2a (Mus musculus)6480464CTDarsenite results in increased expression of CDKN2A mRNAPMID:33010264
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