GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | GCLC | increases expression | EXP | | 6480464 | CTD | arsenite results in increased expression of GCLC mRNA; arsenite results in increased expression of GCLC protein | PMID:22476201 | GCLC | multiple interactions | EXP | | 6480464 | CTD | [arsenite co-treated with epigallocatechin gallate] results in increased expression of GCLC protein; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of GCLC mRNA; arsenite inhibits the reaction [G3BP1 protein binds to GCLC mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of GCLC mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [arsenite results in increased expression of GCLC mRNA]; NFE2L2 protein affects the reaction [arsenite results in increased expression of GCLC protein] | PMID:22476201 PMID:29572906 PMID:32076005 PMID:32406909 | GCLC | increases expression | ISO | Gclc (Mus musculus) | 6480464 | CTD | arsenite results in increased expression of GCLC mRNA; arsenite results in increased expression of GCLC protein | PMID:15894712 PMID:19328227 PMID:32980394 | GCLC | multiple interactions | ISO | Gclc (Mus musculus) | 6480464 | CTD | 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [arsenite results in increased expression of GCLC mRNA]; [arsenite co-treated with Benzo(a)pyrene] results in increased expression of GCLC mRNA; Acetylcysteine inhibits the reaction [arsenite results in increased expression of GCLC mRNA]; arsenite results in increased activity of [GCLC protein binds to GCLM protein]; arsenite results in increased expression of [GCLC protein binds to GCLM protein]; Cycloheximide inhibits the reaction [arsenite results in increased activity of [GCLC protein binds to GCLM protein]]; Cycloheximide inhibits the reaction [arsenite results in increased expression of [GCLC protein binds to GCLM protein]]; Cycloheximide inhibits the reaction [arsenite results in increased expression of GCLC mRNA]; NFE2L1 alternative form affects the reaction [arsenite results in increased expression of GCLC mRNA]; pyrazolanthrone promotes the reaction [arsenite results in increased expression of GCLC mRNA] | PMID:15894712 PMID:19328227 PMID:32980394 | | ||||||||||||||||||||||
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