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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects expressionEXP 6480464CTDarsenite affects the expression of NQO1 protein

PMID:22476201
decreases response to substanceEXP 6480464CTDNQO1 protein results in decreased susceptibility to arsenite

PMID:16494910
increases expressionEXP 6480464CTDarsenite results in increased expression of NQO1 mRNA, arsenite results in increased expression of NQO1 protein

PMID:16494910, PMID:22476201, PMID:25680285
multiple interactionsEXP 6480464CTD[arsenite results in increased expression of NQO1 protein] which results in decreased susceptibility to Doxorubicin, [arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin, [lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA, Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin], Dicumarol inhibits the reaction [NQO1 protein results in decreased susceptibility to arsenite], KEAP1 protein affects the reaction [arsenite results in increased expression of NQO1 mRNA], NFE2L2 mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA], NFE2L2 protein affects the reaction [arsenite affects the expression of NQO1 protein], NFE2L2 protein affects the reaction [arsenite results in increased expression of NQO1 mRNA]

PMID:16494910, PMID:22476201, PMID:25680285
increases activityISORGD:104736480464CTDarsenite results in increased activity of NQO1 protein

PMID:18474416
increases degradationISORGD:104736480464CTDarsenite results in increased degradation of NQO1 mRNA

PMID:18474416
increases expressionISORGD:104736480464CTDarsenite results in increased expression of NQO1 mRNA

PMID:15345372, PMID:15894712, PMID:18474416, PMID:19933842, PMID:25680285
multiple interactionsISORGD:104736480464CTD[arsenite co-treated with Benzo(a)pyrene] results in increased expression of NQO1 mRNA, [lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA, arsenite affects the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein], arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA], Cycloheximide inhibits the reaction [arsenite results in increased expression of NQO1 mRNA], NFE2L2 gene mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA], NFE2L2 gene mutant form inhibits the reaction [arsenite results in increased expression of NQO1 mRNA]

PMID:15894712, PMID:18474416, PMID:25680285
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.