GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Keap1 | affects response to substance | ISO | KEAP1 (Homo sapiens) | 6480464 | CTD | KEAP1 protein affects the susceptibility to arsenite | PMID:22476201 | Keap1 | decreases expression | ISO | KEAP1 (Homo sapiens) | 6480464 | CTD | arsenite results in decreased expression of KEAP1 mRNA; arsenite results in decreased expression of KEAP1 protein | PMID:22476201 | Keap1 | increases expression | ISO | KEAP1 (Homo sapiens) | 6480464 | CTD | arsenite results in increased expression of KEAP1 mRNA; arsenite results in increased expression of KEAP1 protein | PMID:22476201 PMID:29572906 | Keap1 | multiple interactions | ISO | KEAP1 (Homo sapiens) | 6480464 | CTD | epigallocatechin gallate promotes the reaction [arsenite results in increased expression of KEAP1 mRNA]; KEAP1 protein affects the reaction [arsenite results in decreased expression of NFE2L1 mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of GCLC mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of GCLC protein]; KEAP1 protein affects the reaction [arsenite results in increased expression of GCLM mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of HMOX1 mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L1 protein]; KEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L2 mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of NFE2L2 protein]; KEAP1 protein affects the reaction [arsenite results in increased expression of NQO1 mRNA]; KEAP1 protein affects the reaction [arsenite results in increased expression of SRXN1 mRNA]; NFE2L2 protein inhibits the reaction [arsenite results in increased expression of KEAP1 mRNA]; NFE2L2 protein inhibits the reaction [arsenite results in increased expression of KEAP1 protein]; NFE2L2 protein promotes the reaction [arsenite results in decreased expression of KEAP1 mRNA]; NFE2L2 protein promotes the reaction [arsenite results in decreased expression of KEAP1 protein] | PMID:22476201 PMID:29572906 | | ||||||||||||||||||||||
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