Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732740
Species: Homo sapiens
RGD Object: Gene
Symbol: CAT
Name: catalase
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CATdecreases activityEXP 6480464CTDarsenite results in decreased activity of CAT proteinPMID:31935557
CATdecreases expressionEXP 6480464CTDarsenite results in decreased expression of CAT mRNA; arsenite results in decreased expression of CAT proteinPMID:18392098 PMID:22040890
CATmultiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in decreased expression of CAT protein]; 5-((2,6-dichlorobenzyl)sulfonyl)-3-((3,5-dimethyl-4-((2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-1,3-dihydro-2H-indol-2-one inhibits the reaction [arsenite results in decreased expression of CAT protein]; [arsenite co-treated with Curcumin] results in increased expression of CAT protein; CAT protein inhibits the reaction [arsenite results in increased expression of MIR21 mRNA]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK1 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of RELA protein]PMID:18392098 PMID:22040890 PMID:22387281
CATdecreases activityISOCat (Rattus norvegicus)6480464CTDarsenite results in decreased activity of CAT proteinPMID:34339004
CATdecreases expressionISOCat (Mus musculus)6480464CTDarsenite results in decreased expression of CAT mRNA; arsenite results in decreased expression of CAT proteinPMID:20096321 PMID:33010264
CATdecreases oxidationISOCat (Rattus norvegicus)6480464CTDCAT protein results in decreased oxidation of arsenitePMID:18619986
CATdecreases response to substanceISOCat (Mus musculus)6480464CTDCAT protein results in decreased susceptibility to arsenitePMID:9548797
CATincreases expressionISOCat (Mus musculus)6480464CTDarsenite results in increased expression of CAT mRNAPMID:18929588
CATmultiple interactionsISOCat (Rattus norvegicus)6480464CTD[CAT protein results in decreased oxidation of arsenite] which results in decreased chemical synthesis of arsenic acid; Telmisartan inhibits the reaction [arsenite results in decreased activity of CAT protein]PMID:18619986 PMID:34339004
CATmultiple interactionsISOCat (Mus musculus)6480464CTDCAT protein inhibits the reaction [arsenite results in increased expression of MIR21 mRNA]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK1 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of MAPK3 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK1 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of MAPK3 protein]; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of RELA protein]; Tea inhibits the reaction [arsenite results in decreased expression of CAT protein]PMID:14516795 PMID:20096321 PMID:22387281
Go Back to source page   Continue to Ontology report