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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732480
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPB1
Name: heat shock protein family B (small) member 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPB1multiple interactionsEXP 6480464CTDarsenite promotes the reaction [G3BP1 protein binds to HSPB1 mRNA]PMID:32406909
HSPB1increases expressionISOHspb1 (Rattus norvegicus)6480464CTDarsenite results in increased expression of HSPB1 proteinPMID:15175009
HSPB1increases expressionISOHspb1 (Mus musculus)6480464CTDarsenite results in increased expression of HSPB1 mRNAPMID:15894712
HSPB1multiple interactionsISOHspb1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [arsenite results in increased expression of HSPB1 protein]; Glutathione inhibits the reaction [arsenite results in increased expression of HSPB1 protein]PMID:15175009
HSPB1multiple interactionsISOHspb1 (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPB1 mRNAPMID:15894712
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