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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69253
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pitx1
Name: paired-like homeodomain 1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pitx1increases methylationISOPITX1 (Homo sapiens)6480464CTDarsenite results in increased methylation of PITX1 promoterPMID:23974009
Pitx1multiple interactionsISOPITX1 (Homo sapiens)6480464CTD[sodium arsenite results in increased abundance of arsenite] which results in decreased expression of PITX1 mRNAPMID:32076005
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