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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68533
Species: Homo sapiens
RGD Object: Gene
Symbol: MTOR
Name: mechanistic target of rapamycin kinase
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MTORmultiple interactionsEXP 6480464CTD[sodium arsenite results in increased abundance of arsenite] which results in increased phosphorylation of MTOR protein; arsenite inhibits the reaction [G3BP1 protein binds to MTOR mRNA]PMID:31781319 PMID:32406909
MTORincreases phosphorylationISOMtor (Mus musculus)6480464CTDarsenite results in increased phosphorylation of MTOR proteinPMID:23396362
MTORmultiple interactionsISOMtor (Rattus norvegicus)6480464CTDarsenite results in decreased expression of and results in decreased phosphorylation of MTOR protein; Selenium inhibits the reaction [arsenite results in decreased expression of and results in decreased phosphorylation of MTOR protein]PMID:29324385
MTORmultiple interactionsISOMtor (Mus musculus)6480464CTDSirolimus inhibits the reaction [arsenite results in increased phosphorylation of MTOR protein]PMID:23396362
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