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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68384
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ccnd1
Name: cyclin D1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:685566480464CTDarsenite results in increased expression of CCND1 mRNA, arsenite results in increased expression of CCND1 protein

PMID:18197291, PMID:19059425, PMID:21040761, PMID:28444938
increases expressionISORGD:685576480464CTDarsenite results in increased expression of CCND1 mRNA, arsenite results in increased expression of CCND1 protein

PMID:18191166, PMID:19059425
multiple interactionsISORGD:685566480464CTDdecitabine inhibits the reaction [arsenite results in increased expression of CCND1 protein], U 0126 inhibits the reaction [arsenite results in increased expression of CCND1 protein]

PMID:21040761
multiple interactionsISORGD:685576480464CTDJUN mutant form inhibits the reaction [arsenite results in increased expression of CCND1 mRNA]

PMID:19059425
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.