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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDarsenite results in increased activity of CASP12 protein

PMID:18077580, PMID:18226606
multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [arsenite results in increased activity of CASP12 protein], GDNF protein inhibits the reaction [arsenite results in increased activity of CASP12 protein], salubrinal inhibits the reaction [arsenite results in increased activity of CASP12 protein]

PMID:18077580, PMID:18226606
increases expressionISORGD:13480776480464CTDarsenite results in increased expression of CASP12 protein

PMID:26677073
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.