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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620944
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp7
Name: caspase 7
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp7increases activityISOCASP7 (Homo sapiens)6480464CTDarsenite results in increased activity of CASP7 proteinPMID:22260869
Casp7increases activityISOCasp7 (Mus musculus)6480464CTDarsenite results in increased activity of CASP7 proteinPMID:18316066
Casp7increases expressionISOCASP7 (Homo sapiens)6480464CTDarsenite results in increased expression of CASP7 proteinPMID:26677073
Casp7multiple interactionsISOCASP7 (Homo sapiens)6480464CTD[arsenite results in decreased activity of PARP1 protein] which results in decreased cleavage of and results in decreased activity of CASP7 protein; Acetylcysteine inhibits the reaction [arsenite results in increased activity of CASP7 protein]; arsenite results in decreased cleavage of and results in decreased activity of CASP7 protein; TP53 mutant form inhibits the reaction [arsenite results in increased activity of CASP7 protein]PMID:22260869 PMID:22387748
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