GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tgfa | decreases expression | ISO | TGFA (Homo sapiens) | 6480464 | CTD | arsenite results in decreased expression of TGFA mRNA | PMID:31646340 | Tgfa | increases expression | ISO | TGFA (Homo sapiens) | 6480464 | CTD | arsenite results in increased expression of TGFA mRNA; arsenite results in increased expression of TGFA protein | PMID:25257954 | Tgfa | increases methylation | ISO | TGFA (Homo sapiens) | 6480464 | CTD | arsenite results in increased methylation of TGFA promoter | PMID:23974009 | Tgfa | multiple interactions | ISO | TGFA (Homo sapiens) | 6480464 | CTD | arsenite results in increased expression of and results in increased secretion of TGFA protein; EGFR affects the reaction [arsenite results in increased secretion of TGFA protein]; ERBB2 affects the reaction [arsenite results in increased secretion of TGFA protein]; Fulvestrant inhibits the reaction [arsenite results in decreased expression of TGFA mRNA] | PMID:31646340 PMID:31773452 | | ||||||||||||||||||||||
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