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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3715
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc6a3
Name: solute carrier family 6 member 3
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc6a3decreases expressionEXP 6480464CTDarsenite results in decreased expression of SLC6A3 proteinPMID:29982692
Slc6a3decreases expressionISOSlc6a3 (Mus musculus)6480464CTDarsenite results in decreased expression of SLC6A3 mRNA; arsenite results in decreased expression of SLC6A3 proteinPMID:29982692 PMID:33053406
Slc6a3increases response to substanceISOSLC6A3 (Homo sapiens)6480464CTDSLC6A3 protein results in increased susceptibility to arsenitePMID:29566083
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