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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2321145
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fbxw7
Name: F-box and WD repeat domain containing 7
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fbxw7increases response to substanceISOFBXW7 (Homo sapiens)6480464CTDFBXW7 gene mutant form results in increased susceptibility to arsenitePMID:24457827
Fbxw7multiple interactionsISOFBXW7 (Homo sapiens)6480464CTD[FBXW7 gene mutant form results in increased susceptibility to arsenite] which results in increased expression of MYC protein; FBXW7 gene mutant form promotes the reaction [arsenite results in increased cleavage of CASP3 protein]PMID:24457827
Fbxw7multiple interactionsISOFbxw7 (Mus musculus)6480464CTDFBXW7 protein inhibits the reaction [arsenite results in increased cleavage of CASP3 protein]; FBXW7 protein inhibits the reaction [arsenite results in increased expression of MYC protein]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite inhibits the reaction [Cycloheximide inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased degradation of and results in increased expression of MYC protein]]]]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite results in decreased degradation of and results in increased expression of MYC protein]]; FBXW7 protein promotes the reaction [NFKB1 gene mutant form inhibits the reaction [arsenite results in increased cleavage of CASP3 protein]]PMID:24457827
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