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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1349475
Species: Homo sapiens
RGD Object: Gene
Symbol: HSPA1A
Name: heat shock protein family A (Hsp70) member 1A
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HSPA1Aincreases expressionEXP 6480464CTDarsenite results in increased expression of HSPA1A mRNA; arsenite results in increased expression of HSPA1A proteinPMID:16132727 PMID:32406909
HSPA1Amultiple interactionsEXP 6480464CTDarsenite promotes the reaction [G3BP1 protein binds to HSPA1A mRNA]; arsenite promotes the reaction [G3BP1 protein binds to HSPA1A protein]; G3BP1 protein affects the reaction [arsenite results in increased expression of HSPA1A protein]PMID:32406909
HSPA1Aincreases expressionISOHspa1a (Mus musculus)6480464CTDarsenite results in increased expression of HSPA1A mRNAPMID:15894712
HSPA1Amultiple interactionsISOHspa1a (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in increased expression of HSPA1A mRNAPMID:15894712
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