GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nqo1 | increases activity | EXP | | 6480464 | CTD | arsenite results in increased activity of NQO1 protein | PMID:18474416 | Nqo1 | increases degradation | EXP | | 6480464 | CTD | arsenite results in increased degradation of NQO1 mRNA | PMID:18474416 | Nqo1 | increases expression | EXP | | 6480464 | CTD | arsenite results in increased expression of NQO1 mRNA | PMID:15345372 PMID:15894712 PMID:18474416 PMID:19933842 PMID:25680285 PMID:32980394 | Nqo1 | multiple interactions | EXP | | 6480464 | CTD | [arsenite co-treated with Benzo(a)pyrene] results in increased expression of NQO1 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA; arsenite affects the reaction [Tetrachlorodibenzodioxin results in increased activity of NQO1 protein]; arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of NQO1 mRNA]; Cycloheximide inhibits the reaction [arsenite results in increased expression of NQO1 mRNA]; NFE2L1 alternative form affects the reaction [arsenite results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [arsenite results in increased expression of NQO1 mRNA] | PMID:15894712 PMID:18474416 PMID:25680285 PMID:32980394 | Nqo1 | affects expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | arsenite affects the expression of NQO1 protein | PMID:22476201 | Nqo1 | decreases response to substance | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | NQO1 protein results in decreased susceptibility to arsenite | PMID:16494910 | Nqo1 | increases expression | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | arsenite results in increased expression of NQO1 mRNA; arsenite results in increased expression of NQO1 protein | PMID:16494910 PMID:22476201 PMID:25680285 PMID:29572906 PMID:33451022 | Nqo1 | multiple interactions | ISO | NQO1 (Homo sapiens) | 6480464 | CTD | [arsenite results in increased expression of NQO1 protein] which results in decreased susceptibility to Doxorubicin; [arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin; [lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA; [sodium arsenite results in increased abundance of arsenite] which results in increased expression of NQO1 mRNA; arsenite promotes the reaction [G3BP1 protein binds to NQO1 mRNA]; Dicumarol inhibits the reaction [[arsenite results in increased expression of NQO1 protein] which results in increased susceptibility to Mitomycin]; Dicumarol inhibits the reaction [NQO1 protein results in decreased susceptibility to arsenite]; epigallocatechin gallate inhibits the reaction [arsenite results in increased expression of NQO1 protein]; KEAP1 protein affects the reaction [arsenite results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with arsenite] results in increased expression of NQO1 mRNA]; NFE2L2 protein affects the reaction [arsenite affects the expression of NQO1 protein]; NFE2L2 protein affects the reaction [arsenite results in increased expression of NQO1 mRNA]; SQSTM1 protein affects the reaction [[sodium arsenite results in increased abundance of arsenite] which results in increased expression of NQO1 mRNA] | PMID:16494910 PMID:22476201 PMID:25680285 PMID:29572906 PMID:31781319 PMID:32076005 PMID:32406909 PMID:33451022 | | ||||||||||||||||||||||
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