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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10368
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2affects transportISOABCC2 (Homo sapiens)6480464CTDABCC2 protein affects the transport of arsenitePMID:34678219
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDarsenite results in increased expression of ABCC2 mRNA; arsenite results in increased expression of ABCC2 proteinPMID:11836020 PMID:34678219
Abcc2increases transportISOAbcc2 (Rattus norvegicus)6480464CTDABCC2 protein results in increased transport of arsenitePMID:17467962
Abcc2multiple interactionsISOABCC2 (Homo sapiens)6480464CTD[sodium arsenite results in increased abundance of arsenite] which results in increased expression of ABCC2 mRNA; ABCC2 protein affects the reaction [sodium selenide results in increased transport of arsenite]; sodium selenide inhibits the reaction [arsenite results in increased expression of ABCC2 protein]; Sodium Selenite inhibits the reaction [arsenite results in increased expression of ABCC2 protein]PMID:32076005 PMID:34678219
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