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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1affects methylationISOCYP19A1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of CYP19A1 5' UTR; Benzo(a)pyrene affects the methylation of CYP19A1 promoterPMID:27901495
Cyp19a1decreases expressionISOCyp19a1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of CYP19A1 mRNA; Benzo(a)pyrene results in decreased expression of CYP19A1 proteinPMID:20920559
Cyp19a1increases expressionISOCYP19A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of CYP19A1 mRNAPMID:20064835 PMID:20106945 PMID:21632981 PMID:24361490
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD[bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Benzo(a)pyrene co-treated with perfluorooctane sulfonic acid] results in decreased expression of CYP19A1 protein; [bisphenol A co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Benzo(a)pyrene co-treated with perfluorooctane sulfonic acid] results in increased expression of CYP19A1 mRNAPMID:34929288
Cyp19a1multiple interactionsISOCyp19a1 (Rattus norvegicus)6480464CTD[Benzo(a)pyrene co-treated with Diethylhexyl Phthalate] results in decreased expression of CYP19A1 mRNA; [Benzo(a)pyrene co-treated with Diethylhexyl Phthalate] results in decreased expression of CYP19A1 proteinPMID:20920559
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