Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737517
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT3
Name: signal transducer and activator of transcription 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT3affects activityEXP 6480464CTDBenzo(a)pyrene affects the activity of STAT3 proteinPMID:20624995
STAT3affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of STAT3 5' UTR; Benzo(a)pyrene affects the methylation of STAT3 intronPMID:27901495 PMID:30157460
STAT3decreases methylationEXP 6480464CTDBenzo(a)pyrene results in decreased methylation of STAT3 promoterPMID:27901495
STAT3multiple interactionsEXP 6480464CTD[AHR protein affects the susceptibility to Benzo(a)pyrene] which affects the phosphorylation of and affects the localization of STAT3 protein; AHR protein affects the reaction [Benzo(a)pyrene promotes the reaction [STAT3 protein binds to SOCS3 protein]]; Benzo(a)pyrene promotes the reaction [STAT3 protein binds to SOCS3 protein]; IL6 protein affects the reaction [[AHR protein affects the susceptibility to Benzo(a)pyrene] which affects the phosphorylation of STAT3 protein]PMID:31748929
STAT3decreases expressionISOStat3 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of STAT3 mRNAPMID:19770486
STAT3increases expressionISOStat3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of STAT3 mRNAPMID:22228805
STAT3increases phosphorylationISOStat3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased phosphorylation of STAT3 proteinPMID:31748929
Go Back to source page   Continue to Ontology report