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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737422
Species: Mus musculus
RGD Object: Gene
Symbol: Nr1d2
Name: nuclear receptor subfamily 1, group D, member 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1d2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of NR1D2 mRNAPMID:20127859
Nr1d2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of NR1D2 mRNAPMID:15034205 PMID:19770486 PMID:22228805 PMID:22610609
Nr1d2multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of NR1D2 mRNA; AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of NR1D2 mRNA]PMID:15034205 PMID:27858113
Nr1d2affects methylationISONR1D2 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of NR1D2 promoterPMID:27901495
Nr1d2decreases expressionISONR1D2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of NR1D2 mRNAPMID:21632981
Nr1d2increases expressionISONR1D2 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of NR1D2 mRNAPMID:20064835
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