GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ADRA2A | increases methylation | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased methylation of ADRA2A 5' UTR; Benzo(a)pyrene results in increased methylation of ADRA2A promoter | PMID:27901495 | ADRA2A | decreases expression | ISO | Adra2a (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of ADRA2A mRNA | PMID:19770486 | ADRA2A | multiple interactions | ISO | Adra2a (Mus musculus) | 6480464 | CTD | Benzo(a)pyrene promotes the reaction [AHR protein binds to ADRA2A promoter] | PMID:19654925 | |
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