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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737149
Species: Homo sapiens
RGD Object: Gene
Symbol: IGF2
Name: insulin like growth factor 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGF2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of IGF2 promoterPMID:27901495
IGF2decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of IGF2 mRNAPMID:26238291
IGF2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of IGF2 mRNAPMID:22316170
IGF2multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of IGF2 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of IGF2 mRNAPMID:17690111
IGF2decreases expressionISOIgf2 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of IGF2 mRNAPMID:22228805
IGF2decreases expressionISOIgf2 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of IGF2 mRNAPMID:21839799
IGF2increases expressionISOIgf2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of IGF2 mRNAPMID:22342234
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