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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736944
Species: Homo sapiens
RGD Object: Gene
Symbol: SYT1
Name: synaptotagmin 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SYT1increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of SYT1 5' UTR; Benzo(a)pyrene results in increased methylation of SYT1 promoterPMID:27901495
SYT1affects methylationISOSyt1 (Mus musculus)6480464CTDBenzo(a)pyrene affects the methylation of SYT1 intronPMID:27901495
SYT1decreases expressionISOSyt1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased expression of SYT1 proteinPMID:21467743
SYT1decreases expressionISOSyt1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of SYT1 mRNAPMID:19770486 PMID:23735875
SYT1increases expressionISOSyt1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of SYT1 mRNAPMID:21839799
SYT1increases expressionISOSyt1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of SYT1 mRNAPMID:21964900
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