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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736637
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1D1
Name: aldo-keto reductase family 1 member D1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1D1affects expressionEXP 6480464CTDBenzo(a)pyrene affects the expression of AKR1D1 mRNAPMID:20106945
AKR1D1affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of AKR1D1 intron; Benzo(a)pyrene affects the methylation of AKR1D1 promoterPMID:27901495 PMID:30157460
AKR1D1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of AKR1D1 mRNAPMID:21632981 PMID:26238291 PMID:32234424
AKR1D1decreases expressionISOAkr1d1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of AKR1D1 mRNAPMID:19770486
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