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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736610
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1b1
Name: aldo-keto reductase family 1 member B
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of AKR1B1 mRNAPMID:20127859 PMID:22228805
Akr1b1decreases methylationISOAKR1B1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of AKR1B1 promoterPMID:27901495
Akr1b1increases expressionISOAkr1b1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of AKR1B1 proteinPMID:16456883
Akr1b1increases expressionISOAKR1B1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of AKR1B1 mRNAPMID:20106945 PMID:22316170 PMID:26238291 PMID:32234424 PMID:32890658
Akr1b1multiple interactionsISOAkr1b1 (Rattus norvegicus)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA; Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein]; sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein]PMID:16456883 PMID:18711122
Akr1b1multiple interactionsISOAKR1B1 (Homo sapiens)6480464CTD[Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNAPMID:17690111
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