GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akr1b1 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased expression of AKR1B1 mRNA | PMID:20127859 PMID:22228805 | Akr1b1 | decreases methylation | ISO | AKR1B1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in decreased methylation of AKR1B1 promoter | PMID:27901495 | Akr1b1 | increases expression | ISO | Akr1b1 (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of AKR1B1 protein | PMID:16456883 | Akr1b1 | increases expression | ISO | AKR1B1 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of AKR1B1 mRNA | PMID:20106945 PMID:22316170 PMID:26238291 PMID:32234424 PMID:32890658 | Akr1b1 | multiple interactions | ISO | Akr1b1 (Rattus norvegicus) | 6480464 | CTD | [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA; Benzo(a)pyrene promotes the reaction [sodium arsenite results in increased expression of AKR1B1 protein]; sodium arsenite promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1B1 protein] | PMID:16456883 PMID:18711122 | Akr1b1 | multiple interactions | ISO | AKR1B1 (Homo sapiens) | 6480464 | CTD | [Benzo(a)pyrene co-treated with 1,2,5,6-dibenzanthracene] affects the expression of AKR1B1 mRNA; [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of AKR1B1 mRNA; [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of AKR1B1 mRNA | PMID:17690111 | |
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