Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736600
Species: Homo sapiens
RGD Object: Gene
Symbol: CD59
Name: CD59 molecule (CD59 blood group)
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CD59affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of CD59 3' UTR; Benzo(a)pyrene affects the methylation of CD59 5' UTRPMID:27901495 PMID:30157460
CD59increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CD59 mRNAPMID:18247414
CD59increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CD59 promoterPMID:27901495
CD59increases mutagenesisEXP 6480464CTDBenzo(a)pyrene results in increased mutagenesis of CD59 proteinPMID:17045307
CD59decreases lipidationISOCd59b (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in decreased lipidation of CD59 proteinPMID:27931811
CD59increases expressionISOCd59b (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CD59B mRNAPMID:22228805
CD59multiple interactionsISOCd59b (Rattus norvegicus)6480464CTD[Benzo(a)pyrene results in increased mutagenesis of and results in decreased activity of PIGA protein] which affects the localization of CD59 protein; [Benzo(a)pyrene results in increased mutagenesis of PIGA gene] which results in decreased expression of CD59 proteinPMID:19965957 PMID:20202993
Go Back to source page   Continue to Ontology report