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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736173
Species: Mus musculus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1, autophagy related
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of BECN1 mRNAPMID:22228805
Becn1increases expressionISOBecn1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of BECN1 mRNA; Benzo(a)pyrene results in increased expression of BECN1 proteinPMID:21839799 PMID:32619457
Becn1increases expressionISOBECN1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of BECN1 proteinPMID:30726812
Becn1multiple interactionsISOBecn1 (Rattus norvegicus)6480464CTD[Resveratrol co-treated with Benzo(a)pyrene] results in increased expression of BECN1 proteinPMID:32619457
Becn1multiple interactionsISOBECN1 (Homo sapiens)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of BECN1 protein]; IGF1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of BECN1 protein]PMID:30726812
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