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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityEXP 6480464CTDBenzo(a)pyrene results in increased activity of NQO1 protein

PMID:30439556
increases expressionEXP 6480464CTDBenzo(a)pyrene metabolite results in increased expression of NQO1 mRNA, Benzo(a)pyrene results in increased expression of NQO1 mRNA, Benzo(a)pyrene results in increased expression of NQO1 protein

PMID:11008122, PMID:12730081, PMID:14645679, PMID:15735009, PMID:15808406, PMID:17253728, PMID:18952161, PMID:19152381, PMID:20106945, PMID:20498004, PMID:21632981, PMID:21714911, PMID:21802500, PMID:22316170, PMID:26238291, PMID:30439556, PMID:30453624, PMID:31255691
multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with Butyric Acid] results in increased activity of NQO1 protein, [Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NQO1 mRNA, [Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NQO1 protein, [Cadmium Chloride co-treated with Benzo(a)pyrene] results in increased expression of NQO1 mRNA, Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased activity of NQO1 protein], Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of NQO1 mRNA], chlorophyllin inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], cobaltous chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Deferoxamine inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NQO1 mRNA], NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NQO1 protein], nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], trichostatin A inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]

PMID:14645679, PMID:19152381, PMID:25170436, PMID:25946486, PMID:30439556
decreases activityISORGD:104736480464CTDBenzo(a)pyrene results in decreased activity of NQO1 protein

PMID:19449198
increases activityISORGD:104736480464CTDBenzo(a)pyrene results in increased activity of NQO1 protein

PMID:15337587, PMID:18694800, PMID:25911668
increases activityISORGD:25036480464CTDBenzo(a)pyrene results in increased activity of NQO1 protein

PMID:16906435, PMID:19497421
increases expressionISORGD:104736480464CTDBenzo(a)pyrene results in increased expression of NQO1 mRNA, Benzo(a)pyrene results in increased expression of NQO1 protein

PMID:14625279, PMID:14645679, PMID:15337587, PMID:15894712, PMID:17682057, PMID:18694800, PMID:19770486, PMID:20713471, PMID:21569818, PMID:21569840, PMID:21715664, PMID:22935520, PMID:24374135, PMID:25230394, PMID:25908611, PMID:26496743, PMID:29906497
increases expressionISORGD:25036480464CTDBenzo(a)pyrene metabolite results in increased expression of NQO1 mRNA, Benzo(a)pyrene results in increased expression of NQO1 mRNA

PMID:11008122, PMID:19497421
multiple interactionsISORGD:104736480464CTD[arsenite co-treated with Benzo(a)pyrene] results in increased expression of NQO1 mRNA, [Azacitidine co-treated with Butyrates] inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], [Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of NQO1 mRNA, [lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the activity of NQO1 protein, [Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Acetylcysteine promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein], AHR mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], AHR mutant form inhibits the reaction [CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], Arsenic promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Azacitidine inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], Benzo(a)pyrene promotes the reaction [NFE2L2 protein binds to NQO1 promoter], Benzo(a)pyrene promotes the reaction [sodium bichromate results in decreased expression of NQO1 mRNA], Benzo(a)pyrene results in increased activity of and results in increased expression of NQO1 protein, Butyrates inhibits the reaction [Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], Cadmium promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Capsaicin inhibits the reaction [Benzo(a)pyrene results in decreased activity of NQO1 protein], CAT protein promotes the reaction [Benzo(a)pyrene promotes the reaction [NFE2L2 protein binds to NQO1 promoter]], CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein], Chromium inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein], Chromium inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], Hydrogen Peroxide inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein], Hydrogen Peroxide inhibits the reaction [CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein]], Lipopolysaccharides inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein], NFE2L2 mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], NFE2L2 mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein], NFE2L2 mutant form inhibits the reaction [CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]], NFE2L2 mutant form inhibits the reaction [CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein]], nickel chloride inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA], POR protein affects the reaction [Benzo(a)pyrene results in increased activity of and results in increased expression of NQO1 protein]

PMID:14625279, PMID:14645679, PMID:15337587, PMID:15894712, PMID:17682057, PMID:19449198, PMID:21362632, PMID:21569840, PMID:22613061, PMID:25911668, PMID:28987381
multiple interactionsISORGD:25036480464CTD[Benzo(a)pyrene co-treated with 1, 2, 5, 6-dibenzanthracene] affects the expression of NQO1 mRNA, [Benzo(a)pyrene co-treated with benzo(b)fluoranthene] affects the expression of NQO1 mRNA, [Benzo(a)pyrene co-treated with fluoranthene] affects the expression of NQO1 mRNA, Dicumarol inhibits the reaction [Benzo(a)pyrene results in increased activity of NQO1 protein]

PMID:18711122, PMID:19497421
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.