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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735849
Species: Homo sapiens
RGD Object: Gene
Symbol: EPO
Name: erythropoietin
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EPOaffects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of EPO promoterPMID:27901495
EPOdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of EPO mRNAPMID:22316170
EPOincreases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of EPO mRNA; Benzo(a)pyrene results in increased expression of EPO proteinPMID:18247414 PMID:35487446
EPOincreases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of EPO 3' UTRPMID:27901495
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