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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735622
Species: Mus musculus
RGD Object: Gene
Symbol: Gdf15
Name: growth differentiation factor 15
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdf15increases expressionEXP 6480464CTDBenzo(a)pyrene metabolite results in increased expression of GDF15 mRNA; Benzo(a)pyrene results in increased expression of GDF15 mRNAPMID:21569818 PMID:22228805 PMID:22610609 PMID:32553695
Gdf15multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of GDF15 mRNA; [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of GDF15 mRNAPMID:27858113 PMID:32553695
Gdf15increases expressionISOGDF15 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of GDF15 mRNAPMID:20064835 PMID:20106945 PMID:21632981 PMID:21714911 PMID:21871943 PMID:22178795 PMID:22316170 PMID:26238291 PMID:32234424 PMID:35690182
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