Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735411
Species: Homo sapiens
RGD Object: Gene
Symbol: ADD3
Name: adducin 3
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ADD3affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of ADD3 5' UTR; Benzo(a)pyrene affects the methylation of ADD3 promoterPMID:27901495 PMID:30157460
ADD3decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of ADD3 mRNAPMID:20106945 PMID:21632981
ADD3increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of ADD3 mRNAPMID:21802500
ADD3increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of ADD3 exon; Benzo(a)pyrene results in increased methylation of ADD3 promoterPMID:27901495
ADD3decreases expressionISOAdd3 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of ADD3 mRNAPMID:22228805
ADD3increases expressionISOAdd3 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of ADD3 mRNAPMID:22228805
ADD3multiple interactionsISOAdd3 (Mus musculus)6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of ADD3 mRNA; AHR protein affects the reaction [Benzo(a)pyrene affects the expression of ADD3 mRNA]PMID:22228805 PMID:27858113
Go Back to source page   Continue to Ontology report