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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735109
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Unc5c
Name: unc-5 netrin receptor C
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Unc5caffects methylationISOUNC5C (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of UNC5C intronPMID:30157460
Unc5cincreases methylationISOUNC5C (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of UNC5C 3' UTR; Benzo(a)pyrene results in increased methylation of UNC5C 5' UTR; Benzo(a)pyrene results in increased methylation of UNC5C promoterPMID:27901495
Unc5cmultiple interactionsISOUnc5c (Mus musculus)6480464CTDBenzo(a)pyrene promotes the reaction [AHR protein binds to UNC5C promoter]PMID:19654925
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