GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nfe2l2 | decreases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene results in decreased expression of NFE2L2 protein | PMID:26546711 PMID:35777681 | Nfe2l2 | decreases response to substance | EXP | | 6480464 | CTD | NFE2L2 results in decreased susceptibility to Benzo(a)pyrene | PMID:23056183 | Nfe2l2 | increases activity | EXP | | 6480464 | CTD | Benzo(a)pyrene results in increased activity of NFE2L2 protein | PMID:30114225 PMID:30203046 | Nfe2l2 | increases expression | EXP | | 6480464 | CTD | Benzo(a)pyrene metabolite results in increased expression of NFE2L2 mRNA; Benzo(a)pyrene results in increased expression of NFE2L2 mRNA; Benzo(a)pyrene results in increased expression of NFE2L2 protein | PMID:15034205 PMID:18321868 PMID:21569818 PMID:21569840 PMID:21995607 PMID:28533128 PMID:32417428 PMID:32553695 | Nfe2l2 | multiple interactions | EXP | | 6480464 | CTD | [Benzo(a)pyrene results in increased activity of AHR protein] which results in increased expression of NFE2L2 mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of NFE2L2 mRNA; [chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of NFE2L2 protein; [Curcumin co-treated with Benzo(a)pyrene] affects the localization of NFE2L2 protein; AHR affects the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]; AHR mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]; AHR mutant form inhibits the reaction [CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]]; Benzo(a)pyrene promotes the reaction [AHR protein binds to NFE2L2 promoter]; Benzo(a)pyrene promotes the reaction [NFE2L2 protein binds to GSTA1 gene]; Benzo(a)pyrene promotes the reaction [NFE2L2 protein binds to NQO1 promoter]; Benzo(a)pyrene results in increased expression of and affects the localization of NFE2L2 protein; CAT protein promotes the reaction [Benzo(a)pyrene promotes the reaction [NFE2L2 protein binds to NQO1 promoter]]; CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of and affects the localization of NFE2L2 protein]; CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]; hesperetin inhibits the reaction [Benzo(a)pyrene results in decreased expression of NFE2L2 protein]; NFE2L2 mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 mRNA]]; NFE2L2 mutant form inhibits the reaction [CAT protein promotes the reaction [Benzo(a)pyrene results in increased expression of NQO1 protein]] | PMID:11961136 PMID:18321868 PMID:21569840 PMID:21995607 PMID:25820237 PMID:26546711 PMID:32553695 | Nfe2l2 | affects activity | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the activity of NFE2L2 protein | PMID:20624995 | Nfe2l2 | affects localization | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene affects the localization of NFE2L2 protein | PMID:35405071 | Nfe2l2 | increases expression | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of NFE2L2 mRNA; Benzo(a)pyrene results in increased expression of NFE2L2 protein | PMID:19497421 PMID:36736873 | Nfe2l2 | increases expression | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | Benzo(a)pyrene results in increased expression of NFE2L2 mRNA; Benzo(a)pyrene results in increased expression of NFE2L2 protein | PMID:20106945 PMID:20498004 PMID:21256954 PMID:21507987 PMID:21714911 PMID:35641671 | Nfe2l2 | multiple interactions | ISO | Nfe2l2 (Rattus norvegicus) | 6480464 | CTD | AHR protein affects the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA] | PMID:19497421 | Nfe2l2 | multiple interactions | ISO | NFE2L2 (Homo sapiens) | 6480464 | CTD | 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Benzo(a)pyrene affects the localization of NFE2L2 protein]; [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Ethanol co-treated with Benzo(a)pyrene]] which results in increased expression of NFE2L2 mRNA; [Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NFE2L2 mRNA; [Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NFE2L2 protein; [Ethanol co-treated with Benzo(a)pyrene] results in increased expression of NFE2L2 mRNA; [Resveratrol results in increased expression of and results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Benzo(a)pyrene; [sulforaphane results in increased expression of and results in increased activity of NFE2L2 protein] which results in decreased susceptibility to Benzo(a)pyrene; Benzo(a)pyrene promotes the reaction [[BRCA1 protein binds to NFE2L2 promoter] which results in increased expression of NFE2L2 mRNA]; Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]; Benzo(a)pyrene promotes the reaction [BRCA1 protein binds to NFE2L2 promoter]; BRCA1 protein affects the reaction [Benzo(a)pyrene promotes the reaction [ARNT protein binds to NFE2L2 promoter]]; BRCA1 protein affects the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 protein]; kaempferol inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA]; NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of HMOX1 mRNA]; NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of HMOX1 protein]; NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NQO1 mRNA]; NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of NQO1 protein]; NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of SOD1 mRNA]; NFE2L2 protein affects the reaction [BRCA1 protein affects the susceptibility to Benzo(a)pyrene]; NFE2L2 protein inhibits the reaction [BRCA1 inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; NFE2L2 protein promotes the reaction [Ketoconazole inhibits the reaction [Benzo(a)pyrene results in increased abundance of Reactive Oxygen Species]]; Quercetin inhibits the reaction [Benzo(a)pyrene results in increased expression of NFE2L2 mRNA] | PMID:21256954 PMID:21507987 PMID:21753779 PMID:22192953 PMID:25946486 PMID:35405071 PMID:35412187 | | ||||||||||||||||||||||
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