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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733787
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK5R1
Name: cyclin dependent kinase 5 regulatory subunit 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK5R1decreases expressionEXP 6480464CTDBenzo(a)pyrene metabolite results in decreased expression of CDK5R1 mRNAPMID:26314263
CDK5R1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of CDK5R1 mRNAPMID:32234424
CDK5R1increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CDK5R1 5' UTR; Benzo(a)pyrene results in increased methylation of CDK5R1 promoterPMID:27901495
CDK5R1increases expressionISOCdk5r1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CDK5R1 mRNAPMID:19146932
CDK5R1multiple interactionsISOCdk5r1 (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of and results in increased cleavage of CDK5R1 proteinPMID:34529316
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