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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733341
Species: Homo sapiens
RGD Object: Gene
Symbol: GNAZ
Name: G protein subunit alpha z
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GNAZdecreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of GNAZ mRNAPMID:20106945 PMID:21632981 PMID:26238291
GNAZdecreases methylationISOGnaz (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased methylation of GNAZ 5' UTR; Benzo(a)pyrene results in decreased methylation of GNAZ exonPMID:27901495
GNAZincreases methylationISOGnaz (Mus musculus)6480464CTDBenzo(a)pyrene results in increased methylation of GNAZ intronPMID:27901495
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