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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732989
Species: Homo sapiens
RGD Object: Gene
Symbol: PLCG2
Name: phospholipase C gamma 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PLCG2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of PLCG2 5' UTR; Benzo(a)pyrene affects the methylation of PLCG2 intronPMID:27901495 PMID:30157460
PLCG2decreases expressionEXP 6480464CTDBenzo(a)pyrene metabolite results in decreased expression of PLCG2 mRNA; Benzo(a)pyrene results in decreased expression of PLCG2 mRNAPMID:20064835 PMID:26314263 PMID:31255691 PMID:32234424
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