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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732766
Species: Mus musculus
RGD Object: Gene
Symbol: Ogg1
Name: 8-oxoguanine DNA-glycosylase 1
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ogg1decreases expressionEXP 6480464CTDBenzo(a)pyrene results in decreased expression of OGG1 proteinPMID:29145655
Ogg1increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of OGG1 mRNAPMID:29145655
Ogg1decreases expressionISOOGG1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of OGG1 mRNAPMID:26238291
Ogg1increases methylationISOOGG1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased methylation of OGG1 promoterPMID:27901495
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