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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732638
Species: Mus musculus
RGD Object: Gene
Symbol: Ppara
Name: peroxisome proliferator activated receptor alpha
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pparamultiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with Dietary Fats] results in decreased expression of PPARA protein; Benzo(a)pyrene promotes the reaction [Dietary Fats results in decreased expression of PPARA mRNA]PMID:31730885
Pparaaffects activityISOPPARA (Homo sapiens)6480464CTDBenzo(a)pyrene affects the activity of PPARA proteinPMID:20624995
Pparaaffects methylationISOPPARA (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of PPARA intron; Benzo(a)pyrene affects the methylation of PPARA promoterPMID:27901495 PMID:30157460
Pparadecreases expressionISOPPARA (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased expression of PPARA mRNAPMID:26238291 PMID:32234424
Pparadecreases methylationISOPPARA (Homo sapiens)6480464CTDBenzo(a)pyrene results in decreased methylation of PPARA 5' UTRPMID:27901495
Pparaincreases expressionISOPpara (Rattus norvegicus)6480464CTDBenzo(a)pyrene results in increased expression of PPARA mRNAPMID:20920559
Pparamultiple interactionsISOPpara (Rattus norvegicus)6480464CTD[Benzo(a)pyrene co-treated with Diethylhexyl Phthalate] results in increased expression of PPARA mRNAPMID:20920559
Pparamultiple interactionsISOPPARA (Homo sapiens)6480464CTDBenzo(a)pyrene inhibits the reaction [Estradiol inhibits the reaction [Oleic Acid results in decreased expression of PPARA mRNA]]; Benzo(a)pyrene inhibits the reaction [Estradiol inhibits the reaction [Oleic Acid results in decreased expression of PPARA protein]]PMID:31730885
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